We can change the file association of the Excel file. Please right-click the Excel file and choose Properties. Click the Change button and choose Microsoft Office Excel. Also check the box before: Always use the selected program to open this kind of file.

If the problem persists, try the methods below to resolve the issue:

Method 1: Enable the Ignore Other Applications that use DDE feature

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1.       Click the Office button an then click Excel Options. Excel displays the Excel Options dialog box.

2.       Click Advanced at the left side of the dialog box.

3.       In the General section, make sure the Ignore Other Applications that use Dynamic Data Exchange (DDE) check box is selected.

4.       Click on OK.

If you still cannot double-click on a workbook to open it, try these steps:

Method 2:

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1.       Close Excel completely.

2.       Open a My Computer window.

3.       Choose Tool | Folder Options. You should see the Folder Options dialog box.

Note: If you are Windows Vista, click Start > Search, type Folder Options and search it.

4.       Make sure the File Types tab is displayed.

(Note: This option is not available in Windows 7.)

5.       In the list of registered file types, find and select the entry for XLS (Microsoft Excel Worksheet).

6.       Depending on your version of Windows, click on either the Edit or the Advanced button. You should see the Edit File Type dialog box.

7.       In the list of actions, choose Open.

8.       Click the Edit button. Windows displays the Editing Action dialog box.

9.       The Application Used to Perform Action box contains the actual command line used to start Word. Double-check the line to make sure there are no strange extra filenames at the end of the command line.

10.   Make sure the Use DDE check box is selected, and that the DDE Message box is set to the following: [open("%1")]

11.   Click on OK.

12.   Close all the other open dialog boxes.